{"_id":"chr6:g.151944327C>G","_version":1,"chrom":"6","clingen":{"caid":"CA366213288"},"dbnsfp":{"_license":"http://bit.ly/2VLnQBz","aa":{"alt":"R","codon_degeneracy":[2,2,2,2,2],"codonpos":[3,3,3,3,3],"pos":[305,305,305,305,132],"ref":"S","refcodon":["AGC","AGC","AGC","AGC","AGC"]},"alphamissense":{"pred":["P","P","A"],"rankscore":0.68875,"score":[0.5992,0.5999,0.474]},"alt":"G","altai_neandertal":["C","C"],"ancestral_allele":"C","appris":["principal1","principal1","principal1","principal1"],"bayesdel":{"add_af":{"pred":"D","rankscore":0.69803,"score":0.155726},"no_af":{"pred":"D","rankscore":0.69417,"score":-0.0140872}},"bstatistic":{"converted_rankscore":0.36215,"score":846.0},"cadd":{"phred":16.11,"raw_rankscore":0.2368,"raw_score":1.864418},"cds_strand":["+","+","+","+","+"],"chagyrskaya_neandertal":["C","C"],"chrom":"6","clinpred":{"pred":"D","rankscore":0.46584,"score":0.803371906280518},"dann":{"rankscore":0.59507,"score":0.9932421926265974},"denisova":["C","C"],"deogen2":{"pred":["D","D","D","D","T"],"rankscore":0.91005,"score":[0.690724,0.690724,0.690724,0.690724,0.338078]},"eigen":{"phred_coding":2.101105,"raw_coding":-0.12359878965516,"raw_coding_rankscore":0.36366},"eigen-pc":{"phred_coding":1.78675,"raw_coding":-0.199566063124427,"raw_coding_rankscore":0.31554},"ensembl":{"geneid":["ENSG00000091831","ENSG00000091831","ENSG00000091831","ENSG00000091831","ENSG00000091831"],"proteinid":["ENSP00000405330","ENSP00000342630","ENSP00000387500","ENSP00000206249","ENSP00000394721"],"transcriptid":["ENST00000440973","ENST00000338799","ENST00000443427","ENST00000206249","ENST00000427531"]},"esm1b":{"pred":["T","T","T","T"],"rankscore":0.33777,"score":[-4.731,-4.731,-4.731,-4.731]},"eve":{"class10_pred":["U","U","U","U"],"class20_pred":["U","U","U","U"],"class25_pred":["U","U","U","U"],"class30_pred":["U","U","U","U"],"class40_pred":["B","B","B","B"],"class50_pred":["B","B","B","B"],"class60_pred":["B","B","B","B"],"class70_pred":["B","B","B","B"],"class75_pred":["B","B","B","B"],"class80_pred":["B","B","B","B"],"class90_pred":["B","B","B","B"],"rankscore":0.21931,"score":[0.1732008962373553,0.1732008962373553,0.1732008962373553,0.1732008962373553]},"fathmm":{"converted_rankscore":0.92457,"pred":["D","D","D","D"],"score":[-3.06,-3.06,-3.06,-3.06]},"fathmm-mkl":{"coding_group":"AEFDHCI","coding_pred":"D","coding_rankscore":0.77499,"coding_score":0.97837},"fathmm-xf":{"coding_pred":"N","coding_rankscore":0.36108,"coding_score":0.23906},"fitcons":{"gm12878":{"confidence_value":0,"rankscore":0.14657,"score":0.547309},"h1-hesc":{"confidence_value":0,"rankscore":0.23631,"score":0.573888},"huvec":{"confidence_value":0,"rankscore":0.26826,"score":0.564101},"integrated":{"confidence_value":0,"rankscore":0.14033,"score":0.487112}},"gencode_basic":["Y","Y","Y","Y","Y"],"genename":["ESR1","ESR1","ESR1","ESR1","ESR1"],"genocanyon":{"rankscore":0.0796,"score":0.000890476560450387},"gerp":{"91_mammals":{"rankscore":0.26725,"score":0.709}},"gerp++":{"nr":5.66,"rs":1.9,"rs_rankscore":0.2477},"gmvp":{"rankscore":0.77326,"score":0.7737611419029912},"hg18":{"end":152307155,"start":152307155},"hg19":{"end":152265462,"start":152265462},"hg38":{"end":151944327,"start":151944327},"hgvsc":["c.915C>G","c.396C>G"],"hgvsp":["p.Ser305Arg","p.Ser132Arg","p.S305R","p.S132R"],"list-s2":{"pred":["D","D"],"rankscore":0.87236,"score":[0.962604,0.965403]},"lrt":{"converted_rankscore":0.37364,"omega":0.347814,"pred":"N","score":0.002055},"m-cap":{"pred":"D","rankscore":0.87317,"score":0.211683},"metalr":{"pred":"D","rankscore":0.92457,"score":0.778},"metarnn":{"pred":["T","T","T","T","T"],"rankscore":0.49789,"score":[0.32468855,0.32468855,0.32468855,0.32468855,0.32468855]},"metasvm":{"pred":"D","rankscore":0.90128,"score":0.4705},"mpc":{"rankscore":0.55374,"score":0.604265016282},"mutationassessor":{"pred":["M","M","M","M"],"rankscore":0.82945,"score":[2.855,2.855,2.855,2.855]},"mutationtaster":{"aae":["S305R","S305R","S305R","S305R","S132R"],"converted_rankscore":0.81001,"model":["simple_aae","simple_aae","simple_aae","simple_aae","simple_aae","without_aae","without_aae"],"pred":["D","D","D","D","D","D","D"],"score":[0.98356,0.98356,0.98356,0.98356,0.98356,1.0,1.0]},"mutformer":{"rankscore":0.94889,"score":0.9726945},"mutpred":{"aa_change":["S305R","S305R","S305R","S305R"],"accession":["P03372","P03372","P03372","P03372"],"pred":[{"mechanism":"Gain of MoRF binding","p_val":0.0254},{"mechanism":"Gain of MoRF binding","p_val":0.0254},{"mechanism":"Gain of MoRF binding","p_val":0.0254},{"mechanism":"Gain of MoRF binding","p_val":0.0254}],"rankscore":0.33302,"score":[0.341,0.341,0.341,0.341]},"mvp":{"rankscore":0.89647,"score":[0.897487082567,0.897487082567,0.897487082567,0.897487082567,0.897487082567]},"phactboost":{"rankscore":0.57348,"score":[0.390868405087729,0.390868405087729,0.390868405087729,0.390868405087729]},"phastcons":{"100way_vertebrate":{"rankscore":0.36992,"score":0.99},"17way_primate":{"rankscore":0.35893,"score":0.753},"470way_mammalian":{"rankscore":0.28324,"score":0.921}},"phylop":{"100way_vertebrate":{"rankscore":0.19391,"score":0.326},"17way_primate":{"rankscore":0.0342,"score":-0.773},"470way_mammalian":{"rankscore":0.14796,"score":0.112}},"polyphen2":{"hdiv":{"pred":["P","P","P","P"],"rankscore":0.52768,"score":[0.94,0.94,0.94,0.94]},"hvar":{"pred":["P","P","P","P"],"rankscore":0.52893,"score":[0.663,0.663,0.663,0.663]}},"primateai":{"pred":"T","rankscore":0.39532,"score":0.505053520203},"provean":{"converted_rankscore":0.52612,"pred":["N","N","N","N"],"score":[-2.39,-2.39,-2.39,-2.39]},"ref":"C","reliability_index":10,"revel":{"rankscore":0.81888,"score":[0.559,0.559,0.559,0.559]},"rsid":"rs1242811639","sift":{"converted_rankscore":0.20607,"pred":["T","T","T","T"],"score":[0.197,0.197,0.197,0.197]},"sift4g":{"converted_rankscore":0.15355,"pred":["T","T","T","T","T"],"score":[0.418,0.418,0.418,0.418,0.393]},"siphy_29way":{"logodds_rankscore":0.4526,"logodds_score":10.7249,"pi":{"a":0.0,"c":0.6783,"g":0.0,"t":0.3217}},"tsl":[5,5,5,1,1],"uniprot":[{"acc":"P03372","entry":"ESR1_HUMAN"},{"acc":"P03372","entry":"ESR1_HUMAN"},{"acc":"P03372","entry":"ESR1_HUMAN"},{"acc":"P03372","entry":"ESR1_HUMAN"},{"acc":"H0Y4W6","entry":"H0Y4W6_HUMAN"}],"varity":{"er":{"rankscore":0.37643,"score":[0.16194281,0.16194281,0.16194281,0.16194281]},"er_loo":{"rankscore":0.37642,"score":[0.16194281,0.16194281,0.16194281,0.16194281]},"r":{"rankscore":0.55125,"score":[0.3258079,0.3258079,0.3258079,0.3258079]},"r_loo":{"rankscore":0.55125,"score":[0.3258079,0.3258079,0.3258079,0.3258079]}},"vep_canonical":"YES","vest4":{"rankscore":0.30118,"score":[0.259,0.258,0.26,0.266,0.239]},"vindijia_neandertal":["C","C"]},"dbsnp":{"_license":"http://bit.ly/2AqoLOc","alt":"G","chrom":"6","dbsnp_build":156,"gene":{"geneid":2099,"is_pseudo":false,"name":"estrogen receptor 1","rnas":[{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1143,"seq_id":"NM_000125.4"},"hgvs":"NM_000125.4:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_000116.2"}}},"protein_product":{"refseq":"NP_000116.2"},"refseq":"NM_000125.4","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1296,"seq_id":"NM_001122740.2"},"hgvs":"NM_001122740.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001116212.1"}}},"protein_product":{"refseq":"NP_001116212.1"},"refseq":"NM_001122740.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1098,"seq_id":"NM_001122741.2"},"hgvs":"NM_001122741.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001116213.1"}}},"protein_product":{"refseq":"NP_001116213.1"},"refseq":"NM_001122741.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1251,"seq_id":"NM_001122742.2"},"hgvs":"NM_001122742.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001116214.1"}}},"protein_product":{"refseq":"NP_001116214.1"},"refseq":"NM_001122742.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1104,"seq_id":"NM_001291230.2"},"hgvs":"NM_001291230.2:c.921=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":306,"seq_id":"NP_001278159.1"}}},"protein_product":{"refseq":"NP_001278159.1"},"refseq":"NM_001291230.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1095,"seq_id":"NM_001291241.2"},"hgvs":"NM_001291241.2:c.912=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":303,"seq_id":"NP_001278170.1"}}},"protein_product":{"refseq":"NP_001278170.1"},"refseq":"NM_001291241.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":625,"seq_id":"NM_001328100.2"},"hgvs":"NM_001328100.2:c.396=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":131,"seq_id":"NP_001315029.1"}}},"protein_product":{"refseq":"NP_001315029.1"},"refseq":"NM_001328100.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1205,"seq_id":"NM_001385568.1"},"hgvs":"NM_001385568.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001372497.1"}}},"protein_product":{"refseq":"NP_001372497.1"},"refseq":"NM_001385568.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1291,"seq_id":"NM_001385569.1"},"hgvs":"NM_001385569.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001372498.1"}}},"protein_product":{"refseq":"NP_001372498.1"},"refseq":"NM_001385569.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1251,"seq_id":"NM_001385570.1"},"hgvs":"NM_001385570.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001372499.1"}}},"protein_product":{"refseq":"NP_001372499.1"},"refseq":"NM_001385570.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1291,"seq_id":"NM_001385571.1"},"hgvs":"NM_001385571.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001372500.1"}}},"protein_product":{"refseq":"NP_001372500.1"},"refseq":"NM_001385571.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1143,"seq_id":"NM_001385572.1"},"hgvs":"NM_001385572.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"NP_001372501.1"}}},"protein_product":{"refseq":"NP_001372501.1"},"refseq":"NM_001385572.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1365,"seq_id":"XM_011535543.3"},"hgvs":"XM_011535543.3:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_011533845.1"}}},"protein_product":{"refseq":"XP_011533845.1"},"refseq":"XM_011535543.3","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1180,"seq_id":"XM_011535545.3"},"hgvs":"XM_011535545.3:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_011533847.1"}}},"protein_product":{"refseq":"XP_011533847.1"},"refseq":"XM_011535545.3","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1251,"seq_id":"XM_011535547.3"},"hgvs":"XM_011535547.3:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_011533849.1"}}},"protein_product":{"refseq":"XP_011533849.1"},"refseq":"XM_011535547.3","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":2698,"seq_id":"XM_011535549.3"},"hgvs":"XM_011535549.3:c.186=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":61,"seq_id":"XP_011533851.1"}}},"protein_product":{"refseq":"XP_011533851.1"},"refseq":"XM_011535549.3","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1264,"seq_id":"XM_017010377.2"},"hgvs":"XM_017010377.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_016865866.1"}}},"protein_product":{"refseq":"XP_016865866.1"},"refseq":"XM_017010377.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1255,"seq_id":"XM_017010378.2"},"hgvs":"XM_017010378.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_016865867.1"}}},"protein_product":{"refseq":"XP_016865867.1"},"refseq":"XM_017010378.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":6298,"seq_id":"XM_017010379.2"},"hgvs":"XM_017010379.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_016865868.1"}}},"protein_product":{"refseq":"XP_016865868.1"},"refseq":"XM_017010379.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1074,"seq_id":"XM_017010380.2"},"hgvs":"XM_017010380.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_016865869.1"}}},"protein_product":{"refseq":"XP_016865869.1"},"refseq":"XM_017010380.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1004,"seq_id":"XM_017010381.2"},"hgvs":"XM_017010381.2:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_016865870.1"}}},"protein_product":{"refseq":"XP_016865870.1"},"refseq":"XM_017010381.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":4764,"seq_id":"XM_017010383.2"},"hgvs":"XM_017010383.2:c.126=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":41,"seq_id":"XP_016865872.1"}}},"protein_product":{"refseq":"XP_016865872.1"},"refseq":"XM_017010383.2","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1168,"seq_id":"XM_047418289.1"},"hgvs":"XM_047418289.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274245.1"}}},"protein_product":{"refseq":"XP_047274245.1"},"refseq":"XM_047418289.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":10890,"seq_id":"XM_047418290.1"},"hgvs":"XM_047418290.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274246.1"}}},"protein_product":{"refseq":"XP_047274246.1"},"refseq":"XM_047418290.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1098,"seq_id":"XM_047418291.1"},"hgvs":"XM_047418291.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274247.1"}}},"protein_product":{"refseq":"XP_047274247.1"},"refseq":"XM_047418291.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1296,"seq_id":"XM_047418292.1"},"hgvs":"XM_047418292.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274248.1"}}},"protein_product":{"refseq":"XP_047274248.1"},"refseq":"XM_047418292.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1291,"seq_id":"XM_047418293.1"},"hgvs":"XM_047418293.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274249.1"}}},"protein_product":{"refseq":"XP_047274249.1"},"refseq":"XM_047418293.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1168,"seq_id":"XM_047418294.1"},"hgvs":"XM_047418294.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274250.1"}}},"protein_product":{"refseq":"XP_047274250.1"},"refseq":"XM_047418294.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1255,"seq_id":"XM_047418295.1"},"hgvs":"XM_047418295.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274251.1"}}},"protein_product":{"refseq":"XP_047274251.1"},"refseq":"XM_047418295.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1296,"seq_id":"XM_047418296.1"},"hgvs":"XM_047418296.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274252.1"}}},"protein_product":{"refseq":"XP_047274252.1"},"refseq":"XM_047418296.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1251,"seq_id":"XM_047418297.1"},"hgvs":"XM_047418297.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274253.1"}}},"protein_product":{"refseq":"XP_047274253.1"},"refseq":"XM_047418297.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1143,"seq_id":"XM_047418298.1"},"hgvs":"XM_047418298.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274254.1"}}},"protein_product":{"refseq":"XP_047274254.1"},"refseq":"XM_047418298.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]},{"codon_aligned_transcript_change":{"deleted_sequence":"AGC","inserted_sequence":"AGC","position":1296,"seq_id":"XM_047418299.1"},"hgvs":"XM_047418299.1:c.915=","protein":{"variant":{"spdi":{"deleted_sequence":"S","inserted_sequence":"S","position":304,"seq_id":"XP_047274255.1"}}},"protein_product":{"refseq":"XP_047274255.1"},"refseq":"XM_047418299.1","so":[{"accession":"SO:0001580","name":"coding_sequence_variant"}]}],"strand":"+","symbol":"ESR1"},"hg38":{"end":151944327,"start":151944327},"ref":"C","rsid":"rs1242811639","vartype":"snv"},"hg38":{"end":151944327,"start":151944327},"observed":true,"snpeff":{"_license":"http://bit.ly/2suyRKt","ann":[{"effect":"structural_interaction_variant","feature_id":"1A52:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1G50:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWR:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B1Z:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2BJ4:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_474:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2G5O:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2QGW:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2YAT:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3HM1:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q95:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_474:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UU7:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUA:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUC:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUD:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IU7:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IUI:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_474:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_474:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVY:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW8:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWC:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWF:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG5:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG6:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG7:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG8:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG9:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGB:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGD:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PP6:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:A_305-A_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PXM:B_305-B_369:NM_001122742.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1A52:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1G50:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWR:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B1Z:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2BJ4:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_474:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2G5O:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2QGW:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2YAT:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3HM1:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q95:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_474:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UU7:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUA:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUC:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUD:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IU7:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IUI:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_474:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_474:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVY:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW8:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWC:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWF:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG5:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG6:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG7:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG8:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG9:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGB:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGD:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PP6:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:A_305-A_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PXM:B_305-B_369:NM_001122741.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1A52:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1G50:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWR:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B1Z:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2BJ4:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_474:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2G5O:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2QGW:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2YAT:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3HM1:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q95:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_474:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UU7:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUA:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUC:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUD:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IU7:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IUI:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_474:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_474:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVY:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW8:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWC:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWF:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG5:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG6:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG7:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG8:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG9:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGB:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGD:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PP6:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:A_305-A_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PXM:B_305-B_369:NM_001122740.1","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1A52:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1G50:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWQ:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1GWR:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1L2I:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1PCG:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"1ZKY:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B1Z:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2B23:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2BJ4:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2FAI:B_305-B_474:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2G5O:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2QGW:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"2YAT:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3HM1:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q95:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:A_305-A_474:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3Q97:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UU7:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUA:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUC:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"3UUD:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IU7:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IUI:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:A_305-A_474:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV2:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IV4:A_305-A_474:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVW:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IVY:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW6:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IW8:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWC:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4IWF:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG5:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG6:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG7:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG8:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MG9:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGA:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGB:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4MGD:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PP6:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:A_305-A_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PPS:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"effect":"structural_interaction_variant","feature_id":"4PXM:B_305-B_369:NM_000125.3","feature_type":"interaction","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","putative_impact":"HIGH","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"cdna":{"length":"6319","position":"1139"},"cds":{"length":"1794","position":"921"},"effect":"missense_variant","feature_id":"NM_001291230.1","feature_type":"transcript","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.921C>G","hgvs_p":"p.Ser307Arg","protein":{"length":"597","position":"307"},"putative_impact":"MODERATE","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"cdna":{"length":"6465","position":"1285"},"cds":{"length":"1788","position":"915"},"effect":"missense_variant","feature_id":"NM_001122742.1","feature_type":"transcript","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","hgvs_p":"p.Ser305Arg","protein":{"length":"595","position":"305"},"putative_impact":"MODERATE","rank":"6","total":"10","transcript_biotype":"protein_coding"},{"cdna":{"length":"6313","position":"1133"},"cds":{"length":"1788","position":"915"},"effect":"missense_variant","feature_id":"NM_001122741.1","feature_type":"transcript","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","hgvs_p":"p.Ser305Arg","protein":{"length":"595","position":"305"},"putative_impact":"MODERATE","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"cdna":{"length":"6310","position":"1130"},"cds":{"length":"1785","position":"912"},"effect":"missense_variant","feature_id":"NM_001291241.1","feature_type":"transcript","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.912C>G","hgvs_p":"p.Ser304Arg","protein":{"length":"594","position":"304"},"putative_impact":"MODERATE","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"cdna":{"length":"6356","position":"1176"},"cds":{"length":"1788","position":"915"},"effect":"missense_variant","feature_id":"NM_001122740.1","feature_type":"transcript","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","hgvs_p":"p.Ser305Arg","protein":{"length":"595","position":"305"},"putative_impact":"MODERATE","rank":"5","total":"9","transcript_biotype":"protein_coding"},{"cdna":{"length":"6329","position":"1149"},"cds":{"length":"1788","position":"915"},"effect":"missense_variant","feature_id":"NM_000125.3","feature_type":"transcript","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.915C>G","hgvs_p":"p.Ser305Arg","protein":{"length":"595","position":"305"},"putative_impact":"MODERATE","rank":"4","total":"8","transcript_biotype":"protein_coding"},{"cdna":{"length":"5420","position":"628"},"cds":{"length":"933","position":"396"},"effect":"missense_variant","feature_id":"NM_001328100.1","feature_type":"transcript","gene_id":"ESR1","genename":"ESR1","hgvs_c":"c.396C>G","hgvs_p":"p.Ser132Arg","protein":{"length":"310","position":"132"},"putative_impact":"MODERATE","rank":"4","total":"7","transcript_biotype":"protein_coding"}]},"vcf":{"alt":"G","position":"151944327","ref":"C"}}