MyVariant.info provides simple-to-use REST web services to query/retrieve variant annotation data, aggregated from many popular data resources. It’s designed with simplicity and performance emphasized. You can use use it to annotate discovered variants with the up-to-date variant annotation; or query for specific known variants using a combination of your query criteria, especially across multiple data resources (e.g. to get all variants on gene CDK2, having polyphen2 score > 0.99, and also found in cosmic database using this query). MyVariant.info can also be used to power a web application which requires querying or retrieving variant annotations, without the need of maintaining your own local database backend.
The source code of MyVariant.info project is currently hosted at github: https://github.com/biothings/myvariant.info.